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A study by Yale researchers has identified potential immunological patterns associated with "post-vaccination syndrome" (PVS), a condition reported by a small percentage of individuals who received COVID vaccines. Researchers noted that symptoms such as excessive fatigue, brain fog, and dizziness can develop shortly after vaccination, sometimes worsening over time. Co-senior author Akiko Iwasaki stated, "This work is still in its early stages, and we need to validate these findings," suggesting that the discoveries may eventually lead to treatments for those affected.
Analysis of blood samples from participants revealed that those experiencing PVS had lower levels of white blood cells and antibodies against the SARS-CoV-2 spike protein. Researchers observed higher levels of spike protein among some PVS patients, potentially linked to long COVID risks. "Every medical intervention carries some risk, and it’s important to acknowledge that adverse events can occur with vaccines," said co-senior author Harlan Krumholz. The team emphasizes the need for further research to understand the prevalence and underlying causes of PVS.