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A recent study analyzing data from nearly 500,000 participants in the UK BioBank has found that environmental factors are ten times more influential than genetics in determining the risk of premature death. Published in Nature Medicine, the research led by Dr. Austin Argentieri from Harvard and the Broad Institute assessed 164 environmental exposures, including living conditions and smoking habits, to understand their impact on health outcomes.
The team identified 85 different environmental exposures linked to premature death, ultimately narrowing it down to 25 key factors. Notably, factors such as childhood maternal smoking and household income were highlighted, while diet-related aspects were not as clearly linked due to reporting inconsistencies. The study concluded that environmental factors explained 17% of the variation in death risk, contrasting sharply with the less than 2% explained by genetic predisposition for major diseases.
Dr. Stephen Burgess from the University of Cambridge emphasized the significance of these findings, reiterating that while genetics play a role, it is often our environments that shape our health outcomes.